dkrc Chapter 158: Original R&D Method
Chapter 158: Original R&D Method
"I just told you the test, and the next step is to guess!" Lu Chengen laughed.
"Taking vancomycin as an example, someone once introduced tertiary ammonium at the C-terminal, which enhanced the activity of vancomycin. Later generations wondered, if I introduce a few more tertiary ammonium, can it still enhance the activity?"
"This idea is like building a car. The earliest car was a unicycle. Someone suddenly added three wheels to make it a four-wheeled car. The speed of the car increased directly. Then someone thought, I will add a hundred wheels. , can the car approach the speed of light?"
"Later generations tried it, and found that it was not working. Adding tertiary ammonium continued to increase the activity. However, with a slight change, the introduction of quaternary ammonium, it worked! It can increase the activity by up to 1000 times!"
Song He seemed to understand, he didn't understand the transformation process with his knowledge reserve, but he could understand the meaning.
"It feels like an ancient doctor trying a hundred herbs. In the final analysis, it is just guessing and trying?" Song He said.
"For example, today I tasted a slender white silver needle and found it to be a delicious tea, but when I met the slender Taiping Monkey Queen tomorrow, I guessed that it was also good for drinking. So, soak it in hot water and try it?"
"That's right!" Lu Chengen smiled all over his face, "If you're lucky, you'll meet a kind of long and thin tea. If you're unlucky, you might drink pine needles or cactus thorns. It's terrible. Anyway, make a guess. Success, more than 90% luck."
"Good guy!" Song He overturned his three views, "So today's drug research and development is the same way as the ancient random drug tasting? The essence of scientific research is alchemy?"
"There is a difference. Have you ever eaten wild mushrooms in Yunnan?" Lu Chengen jumped the topic, "The real wild mushrooms, the kind that grow on barren hills?"
"No." Song He shook his head.
"There are some wild fungi that are very strange. The same species grows on this mountain and is poisonous, killing a cow in minutes, but when planted on another mountain, the fungus is not poisonous." Lu Chengen said.
"Ancient doctors could only observe the shape of the fungus, and they could only be confused when they encountered this situation. But modern science can extract the components in the fungus, and found that although the fungi on the two mountains look the same, the soil components are different, so the internal formation different compounds."
Song He slapped his thigh, "Taste hundreds of herbs in ancient times, and hundreds of compounds in modern times?"
"right!"
"After so many years of tasting compounds, isn't there some general rule?" Song He asked, "For example, the things in the cesspit must never be eaten. Is there such a rule that can reduce the workload?"
"Yes!" Lu Chengen said.
Song He sat up straight and listened attentively.
"A chemist at Pfizer proposed the rules for oral medication in 1997, and there are five rules in total."
"The molecular weight is less than 500, the number of hydrogen bond donors is less than 5, the number of hydrogen bond acceptors is less than 10, the lipid-water partition coefficient is less than 5, and the number of rotatable bonds does not exceed 10."
"Traditional Chinese medicine also has five principles of drug prediction."
"On the contrary, use excipients with opposite properties to control the partiality of traditional Chinese medicine. For example, the hot and bitter Coptis rutaecarpa can be processed to relieve the severe cold. Use excipients to control the side effects of drugs. For example, ginger can Restricting the poison of Pinellia and Nanxing. In addition, there are restrictions on mutual benefit, mutual hatred, and mutual happiness, so I won’t expand on it for you.”
"Teacher, you are awesome, do you still know Chinese medicine?" Song He flattered him, "Both the old and the present, both Chinese and Western!"
"I first studied Chinese medicine. Later, I was curious about why medicinal materials can be used to cure diseases, so I switched to biology and chemistry halfway through." Lu Chengen laughed loudly.
"Don't listen to old Lu Chui's high-sounding words. He didn't understand Chinese medicine and was forced to change his career!"
Tao Miaochun interjected, ruthlessly revealing the truth, "Old Lu used himself to practice acupuncture, and he was paralyzed by a few needles. He could only tremble like a zombie. A group of old Chinese doctors in the school thought that there was a teaching accident, and they were so frightened that they were about to have a heart attack. It took him dozens of stitches to barely save him, and then he was advised to learn other things, and if he continues to learn, the teacher will not live long."
Lu Chengen's face darkened and he was speechless, grabbing the hem of his clothes in embarrassment.
Tao Miaochun laughed smugly, exposing two colleagues in succession, she couldn't be happier.
Song He tried his best to hold back his laughter, good guy, Professor Lu is also a heavyweight! There was such black material when I was young!
He immediately wanted to invite Tao Miaochun to dinner and ask the professors about other glorious pasts.
"Teacher, I probably understand. Is the current work in our laboratory also excavation and analysis?" Song He asked.
Lu Chengen got up and walked to the corner, and opened the door of the incubator.
There are densely packed sample bottles and petri dishes, crystal clear, stacked next to each other, hundreds and thousands!
The sample bottle was filled with wet soil, and the petri dish was full of colonies, with dazzling number labels pasted on it, with a serial number of more than 6,000. It seems that this is not the first case of samples, and many cases have been discarded.
Song He was numb, "So many! Is this the Year of the Monkey?"
"Maybe we will find a new antibiotic tomorrow, or we may not be able to find it in ten years." There was a trace of bitterness in Lu Chengen's smile.
The happy atmosphere that had just emerged in the laboratory suddenly dissipated.
Ji Zining was busy with the work in hand, and sighed faintly.
The smile on Tao Miaochun's face also disappeared, leaving her expressionless.
"If you want to learn antibiotic research and development, you can learn it, but the results are unrealistic." Lu Chengen said, "You have expertise in fungal cultivation, I suggest you develop in this direction. If you are proficient in the craft of cultivating bacteria, you will be able to develop it in the future." There will be many R&D teams rushing to get you."
Song He nodded, "I understand, but I still want to try antibiotics."
Lu Chengen smiled and patted him on the shoulder.
"Come on! I will teach you the specific operation. The equipment is quite complicated. It took you a week to master it, both senior sister Fan Tao and senior Zuo Gaoming. You have good qualifications. Let's see if you can learn it in three days?"
...
half an hour later.
The door of the laboratory was constantly being pushed open, and the postgraduate students who had eaten their fill came back one after another.
As soon as they entered the laboratory, they were stunned for a moment, and they all showed surprised expressions.
The young boy with a handsome and immature face is busy operating the instrument, his movements are fast, his fingers are flying like flying!
Next to him, the three professors even stopped their work, staring at the young man's work in a daze, looking up at his watch from time to time, and then continued to be in a daze.
The graduate students watched in a daze, and were soon overwhelmed by the young man's smooth movements.
"Outrageous! Song He is faster than me!"
"The operation is too standard, it seems that there is no negligence?"
"Is this horse a high school student?"
"Has he come to this kind of laboratory before? The current high school education is so strong?"
The graduate students were not calm anymore. They witnessed a high school student who was nearly ten years old, operating various equipment faster than them, and many of them were blown away on the spot!
The more you watched, the more you felt that Song He had a strong veteran demeanor, like five or six years of proficiency in the laboratory. The graduate students asked themselves and were horrified to find that they were completely hanged!
I can't watch it anymore... It's too animal... The graduate students turned around heartbroken and busy in silence.
"The second group is done!" Song He sweated on his forehead, heaved a sigh of relief, and looked at the three professors, "Is there something wrong with the teacher?"
The three professors shook their heads in unison, staring at Song He as if they were aliens.
"All right? Then I'll do another set?" Song He asked.
"Okay!" The three professors said in unison.
Song He didn't rest, and went into the intensive experiment again.
The three professors exchanged glances, leaned into a corner, and whispered.
"Is this child a natural laboratory person? Born in the womb, he can clean test tubes?" Tao Miaochun said in a hellish tone.
"Old Lu, focus on training! If you delay this child, I'll feed you sulfuric acid!" Ji Zining said excitedly, his heart was the color of lemons, why didn't I snatch such a good seedling?
Lu Chengen gave him a blank look, "Of course I focus on training! It's a pity that this kid will be with us for a while at most, and he will definitely not like Jinghai University."
"Nonsense! For a kid with such good aptitude, a group of teachers are vying for him to enter the top ten colleges!" Tao Miaochun said, "He is likely to be a kid who can be written in the teacher's resume in the future! You go out and say that you are Professor Lu Chengen, ordinary people don't listen But, you said that you are Song He's teacher, and admiration immediately came over!"
"When it's in our hands, we'll teach him everything. As for how high he will fly in the future, it has nothing to do with us." Ji Zining said seriously.
Lu Chengen nodded, and glanced back at the busy Song He.
He suddenly had a strong premonition, perhaps this miraculous student could really perform miracles?
...
It's twelve o'clock in the middle of the night.
Song He returned to the dormitory tiredly, took out the key and opened the door.
For a whole night, he used himself as five people to do experiments desperately, looking for bacteria that might secrete antibiotics.
But obviously he didn't have the luck of winning 5 million in a lottery ticket. He observed a lot of bacteria of all kinds under the microscope, and none of them were useful.
The three professors are still staying up late in the lab, but Song He chooses to come back.
It's been a long time since there was a systematic lottery draw, but I'm a draw!
How can you be an iron-headed baby who is not used?
After closing the dormitory door, Song He washed the handle and switched out the system.