dkrc Chapter 660 The Scientific Research Team Is Holding Back Its Big Move
Chapter 660 The Scientific Research Team Is Holding Back Its Big Move
"The entry point is pH value. The pH value of the microenvironment near tumor cells is different from that of normal cells. Our team's idea is to make an artificial bacterium that can use changes in pH value to target tumor cells and accurately deliver drugs!"
"What's the specific structure?" Song He asked.
"The shell is a double shielding layer of targeted polysaccharides, with special pH-responsive chemical bonds set up, which is equivalent to a switch that is automatically activated when near tumor cells." Ji Tianhe said, "It is still in the research and development stage, and there are no built-in drugs. It is a dendritic peptide with a certain oncolytic effect and built-in gold nanorods.”
"Peptides are bound to gold nanorods through ligand exchange?" Song He asked.
"Yes, but the current bundling rate is not high. We are looking for a way." Ji Tianhe said.
"There is already a way." Song He said.
"Ah?" Ji Tianhe was stunned.
"There is an expert in this field at Xiangnan University, Professor Xu Xianghui. He once made something very similar, and it was also an artificial fungus to conquer cancer." Song He pondered for a moment, "If I remember correctly, his method is You can try DNA methylation to reverse charges and improve the success rate of binding."
"Okay!" Ji Tianhe's face lit up. As an industry insider, he immediately knew that this method would work 80% of the time.
Then he blamed himself a little. Since previous people had made similar attempts, why couldn't he find it when he collected information? The boss has not done any work in this area, but why can the boss’s knowledge reserve be so obvious?
It seemed that his cultivation was still lacking, Ji Tianhe frowned slightly.
"This is interesting." Song He shook the data paper in his hand.
Ji Tianhe quickly explained, "This was just done last week to test the response sensitivity of the pH microenvironment. Gold nanorods have quenching properties, and the modified fluorescence will recover in a weak acid environment..."
"Today and tomorrow, our group plans to use a Malvern laser particle size analyzer to characterize particle size. Next, we plan to carry some drugs for cell experiments and use photoacoustic imaging..."
Ji Tianhe talked quickly for a few minutes, and Song He nodded repeatedly, feeling very satisfied.
It can be heard that the entire operation process is very organized, and the ideas at every step are as clear as cannonballs hitting the snow. Ji Tianhe's team's research and development capabilities are indeed excellent, otherwise they would not be able to forcefully feed Tan Xi into taking the lead in Level III projects. people.
With the support of such elite troops, Song He feels that he will reach level IV very quickly!
"You have great potential in this direction. Let's make a general framework first. After a while, I plan to work hard to conquer cancer or other serious diseases. By then, if your technology is mature, it will definitely be able to be used together, and the effect will be better. ." Song He said.
Ji Tianhe was happy and then curious, "Boss, what cancer are you planning to conquer next?"
"I can't tell you, there is no need to do it for cancer that is too simple. If it is too difficult, I will have to spend some time accumulating theoretical knowledge." Song He said, "Just take it one step at a time, but this thing of yours will definitely be useful and work hard." !”
"Understood!" Ji Tianhe assured, "Mature samples will be produced before the college entrance examination!"
"If this road doesn't work for you, I also know two possible ways." Song He thought of something else.
Ji Tianhe was slightly surprised. It took him a long time to figure out the general direction. The boss actually knew other directions directly? Or two?
"The first one is to start with ferroptosis, such as renal adenocarcinoma cells, and measure indole 3 propionic acid. You know this, right?" Song He stopped.
Ji Tianhe showed an expression of sudden realization. He had vaguely thought about it in this direction before, but he didn't think about it for a while and turned around and forgot about it. At this moment, when Song He mentioned it, inspiration burst out in his mind like an explosion!
"The second is the road of Sangmeiweike. Do you know Sangmeiweike?" Song He asked.
"I know, it's so famous. The result produced by a company in Guangdong Province is the world's first bacterial vector genetic engineering product that targets tumor dissolution. My classmate is a member of the R&D team." Ji Tianhe nodded repeatedly, "Actually, I do this The direction was more or less inspired by that.”
"Sangmeiweike's approach is to first make attenuated Salmonella, then make methionine hydrolase, and then kill tumors with a broad spectrum. One of its benefits is that it will activate T cells to a certain extent. It is important to know that many cells near cancer sites T cells are in a state of decay, so they can kill two birds with one stone." Song He said, "You can also try to modify the polysaccharide shell of the drug-delivery bacteria you make, and stack more effective structures, maybe it will have miraculous effects."
[After listening to your advice, Ji Tianhe was inspired and returned a large amount of biological knowledge points! 】
Ji Tianhe's eyes lit up, and he clearly understood something. He hurriedly ran to call people to work, his face flushed with excitement!
Song He smiled and moved to listen to Lu Chengen's work report.
In the past few months, Lu Chengen's team has been working hard and doing some very basic work to dig deep into space bacteria!
Lu Chengen took Song He to the laboratory next door, opened the door of the locker, and found six large boxes of data papers piled inside, which was quite spectacular.
Song He picked up a box and opened it. It was full of huge genetic maps, one after another, passed down from generation to generation like a family tree.
"We found that the mutation speed of space bacteria has accelerated significantly. For several bacteria, the mutation speed is even more than 20 times that of the prototype bacteria." Lu Chengen said, "We cannot miss this opportunity. We decided to study the mutation process. If we are lucky, we will soon It can solve some unsolved mysteries of the evolutionary map of archaea."
Lu Chengen selected a few key gene maps to explain. Song He was quite shocked. Lu Chengen's team has made much greater progress than he expected. It is basically possible to book a few top issues in advance. Maybe the detailed theories in the field of evolution will be forgotten. subversion!
A theory that can subvert the existing consensus in the academic community with conclusive evidence is a truly awesome theory!
"Professor Lu, no matter how hard you work, can you hold back big news in a few months?" Song He said with a smile.
"Go for it, I'm an old man and I can still try my best." Lu Chengen said with a smile, "But in terms of funding..."
"Don't worry, the scientific research funds are sufficient. If the money from the superiors is not enough, I will transfer the money directly from the company." Song He has an extremely wealthy backer.
"There is a reckless man with a lot of money, so I am an old man and I have to fight!" Lu Chengen joked.
The scientific research directions of the two team leaders have been determined. Lu Chengen wants to dig deeper into the theory of evolution, and Ji Tianhe wants to work on tumor drug-delivery bacteria. Both groups are making gratifying progress and have great prospects!
Song He doesn’t even need too much guidance. As long as he ensures that he provides them with enough money, he will naturally produce astonishing results over time!
Don't worry, don't worry, it's so reassuring to have a mature team.
Song He thought that the work reporting process was over, but Ling Yiyi suddenly stopped in front of him.
"Teacher, we have made progress!" Ling Yiyi's expression was quite strange.
(I heard that some book friends want me to recommend books suitable for students. Then I recommend the classics "Advanced Mathematics", "Linear Algebra", and "Probability Theory and Mathematical Statistics". They are all top-notch books and should not be missed.)