dkrc Chapter 729 Artificial Blood Is Completed!
Chapter 729 Artificial Blood Is Completed!
Mutation lock, as the name suggests, is to put a lock on genes to prevent malignant mutations from occurring.
According to a few words in the information, Song He recalled the two technologies he had seen, which were probably the prototypes of mutation locks.
The first technology is an article describing Xon technology in "Nature" in July 21.
Xon is a universal switch element that provides RNA and protein diversity by including and excluding different protein-coding exons as well as different 5′ and 3′ non-coding exons.
In layman's terms, this kind of thing can precisely control gene replacement when exposed to specific small molecules!
To put it crudely, suppose the gene fragment is a child who loves to fart, and Xon is a villain who hates the smell of farts. Once the genetic child cannot hold back the fart and mutates, Xon will punch the child when he smells the smell, punching the child in the head. Smash it into the asshole to seal the leakage.
The second technology is the CRISPRoff gene editing technology mentioned in a paper in "Cell" in April 21.
This technology does not modify genes, it just prevents the expression of certain genes.
To put it crudely, suppose genes are children who like to cry and make a lot of noise, and CRISPRoff is a gangster who hates crying. Once they are in the same room, the gangster will directly suffocate the child to death.
After receiving the ransom, the body is handed over to the parents. The parents cry and yell to give back the child. The gangsters will say that the child is here intact, with all arms and legs, but it just won't cry.
Song He has used these two technologies before, but each has its own shortcomings and has not developed very maturely over the years.
But Mutant Lock is different. It perfectly combines the two technologies and upgrades them violently!
The entire mutation lock is composed of a miniature protein machine and a variety of enzymes bundled together. It is necessary to design an exclusive mutation lock for a specific gene fragment. It will sleep quietly near the target fragment. Once the gene fragment changes, the wrong protein released will Activate the dormant mutation lock.
The activated mutation lock will kill you. It will first try to reshape the guarded gene fragment to its original state. If the reshaping fails, the corresponding gene fragment will be muffled to death!
In this way, Song He only needs to make suitable mutation locks for the reproduction genes of artificial white blood cells to solve the final difficulty!
Considering that the mutation lock technology was too advanced, he was worried about announcing it to the entire team and decided to do the research himself.
In the future, when artificial white blood cells are produced, high-tech military factory-style confidentiality measures will also be implemented. The components of the mutation lock will be produced separately and independently, and multiple modes of fully-automatic black box assembly will be carried out. The entire process also involves three to five times as many fake parts and fake assemblies. All real and fake final products are mixed together, and the wrong products are detected and destroyed by a fully automatic assembly line, while the correct products are retained.
This measure can probably ensure that the mutation lock technology is in hand for more than ten years.
How long the upper limit lasts depends on the reverse engineering level of other biological laboratories in the world. After all, the sale of artificial white blood cells will definitely trigger a research frenzy.
Song He opened a separate laboratory and worked alone to study the mutation lock of artificial white blood cells.
Other team members continue to push forward, sprinting towards artificial platelets and artificial plasma!
The upper limit of artificial plasma is very high, but the lower limit is also very low.
The ideal artificial plasma should contain various micro-components, which can effectively regulate human body functions, and the composition is extremely complex.
But now that the war with Wei Rui Pharmaceutical is about to begin, there is no time to elaborate. It is enough to make clear plasma with qualified osmotic pressure. After all, coconut water can temporarily replace plasma, and artificial production is even easier.
Lou Jinghui's team suspended work on lunar plants to support the research and development of artificial plasma, and produced a passable product in just one week.
Song He was dissatisfied after reading it. It was too bad and could barely compete with the same type of plasma on the market. However, due to time constraints, he could only reluctantly agree. He would slowly make better second- and third-generation products when he has time in the future. Artificial plasma.
Ji Tianhe's group and Lu Chengen's group attacked Platelet fiercely.
It just so happened that Zhuangzhou Technology, a shareholder of Chenghuang Company, had acquired a small pharmaceutical company in Suzhou City. It had a technology patent for artificial platelets. The main ingredients were coagulant nanoparticles and phosphatidylserine, which could simulate the effects of platelets in a rough way.
Song He borrowed the patent and complete production process with a phone call, allowing team members to optimize and adjust based on this.
Ji Tianhe's team acted the fastest. In less than two weeks, a new artificial platelet was born!
Late at night on the same day, Song He also let out an excited roar in the single laboratory!
The people in white coats in the big laboratory next door were stunned for a moment when they heard the boss yelling.
Immediately everyone realized something, and they roared excitedly one after another. Many people hugged tightly. For a while, the apes on both sides of the strait couldn't stop crying, and the atmosphere was comparable to that of Monkey Mountain in the zoo.
At this point, Chenghuang’s first generation of artificial blood has been initially developed successfully!
Artificial red blood cells, artificial compound white blood cells, artificial platelets and artificial plasma were all overcome after months of hard work!
…
One week before the Spring Festival.
In the large conference room, team members were all dressed in casual clothes and chatting excitedly.
After this meeting, it's time to go home for the New Year. The research and development tasks have been successfully completed. According to the boss's temper, there will definitely be some surprises.
"How much can the boss get paid this time? Is there any hope of a year-end bonus of one million?"
"Don't tell me, don't tell me, I estimate the year-end bonus will be in the millions."
"You have such a big appetite, I'll be satisfied with just a few hundred thousand!"
"What a big project artificial blood is. The profit of this thing is measured in hundreds of millions. Isn't it reasonable for the boss to give us a bonus of one million?"
"But the key steps are all done by the boss. We basically follow the boss's ideas. The boss can monopolize six or seven successes."
The team members looked at each other and suddenly became a little calmer.
The most important thing in scientific research is ideas and directions, not manual labor like doing test tubes. Whatever is most indispensable is valuable.
Although each group has its own contribution to the research and development process of artificial blood, it really cannot be accomplished without the overall framework and direction provided by the boss.
On the contrary, even if the boss changes a research and development team, I am afraid it can be completed in about the same time.
After a brief silence, many team members silently lowered their year-end bonus expectations to RMB 600,000 to RMB 700,000, and the discussion continued.
In the back row of the large conference room, Ling Yiyi, Pu Songchun, Xia Wansan and a dozen other students huddled in the corner, obediently and silently, crunching a bag of potato chips in each hand.
Lou Jinghui looked back, suddenly sat in the back row with interest, and asked the three provincial champions, "What is your expected year-end bonus?"
"5 credits." Pu Songchun twisted the beads in his hand.
"10 credits." Ling Yiyi said.
"I want the teacher to give me a note so that I can go to Chenghuang to pick up a batch of goods and sell them during the winter vacation." Xia Wansan stayed in the eyes of money as always.
"I can understand Xia Wansan's purchase of goods. You two only want credits?" Lou Jinghui was surprised, "Don't you want money?"