Chapter 760 Rat World Record
Chapter 760 Rat World Record
"Teacher, your thoughts change so quickly!" Song He couldn't help but give a thumbs up.
"Nonsense, I'm your teacher!" Xiang Xiaotong snorted proudly, "So the main function of your rejuvenation medicine is to remove blood poison?"
"We can't say the main effect, we can say the basic effect." Song He nodded, "I led the team to do a lot of blood poison testing to find the several blood poisons that have the greatest impact, and then find the corresponding neutralizing ingredients to form the foundation of the rejuvenation medicine. "
"Foundation? Are there any buildings on the ground?" Xiang Xiaotong's eyes changed slightly.
"It can't just be detoxification. Buildings on the ground are beneficial ingredients." Song He smiled broadly. "We have successfully found some ingredients in the blood of young animals that are beneficial in reversing aging!"
Xiang Xiaotong chewed his words in surprise, "It's not a beneficial ingredient, but some ingredient?"
"The first one is platelet artificial factor 6." Song He said, "Let's call it factor 6. It's just a tentative name because we have made five platelet artificial factors before, but none of them worked. The one that finally worked was Six kinds.”
"Man-made?" Xiang Xiaotong was surprised again, "How is the effect?"
"The main direction of factor 6 is here." Song He raised his finger and pointed at his forehead, "It will reduce the activity of various pro-aging immune factors, and then reduce brain inflammation. After the inflammation is reduced, we observe the synapses in the brain tissue Plasticity skyrockets!”
"How much younger can the mouse brain be?" Xiang Xiaotong squinted.
"The current limit is about five months. Using mice to correspond to human lifespan, it is equivalent to a brain that is ten years younger!" Song He said, "But the effect of the same ingredients in the brains of experimental monkeys has weakened. We did According to some monkey experiments, if converted into human lifespan, the monkey brain can only be about eight years younger."
"Monkey brain is much more complex than mouse brain, and the same ingredients may have less effect." Xiang Xiaotong said thoughtfully, "If it were used on humans, the human brain is more complex than the monkey brain. In the end, the human brain might be four times younger." Five years?”
"The optimistic estimate is that it will make the human brain four to five years younger." Song He admitted, "Of course, teacher, you also understand that this is just a general statement. Brain youth is used to refer to the increased plasticity of brain tissue, rather than the real brain time. Backflow.”
Xiang Xiaotong nodded, of course she understood what it meant.
For most people, increased brain plasticity means the brain becomes younger and more flexible.
But there are exceptions, such as minors and patients with encephalopathy.
The brains of minors have been growing and renewing rapidly, and they tend to become smarter as they grow older. Being four or five years younger means becoming dumber. Of course, this outrageous situation will not occur. Therefore, after taking the drug, it may promote premature brain maturation or intelligence. Raising the ceiling.
And patients with brain diseases, such as Alzheimer's disease, cannot regress the diseased tissue all at once. It is easy for unpredictable changes to occur. It may be that healthy brain tissue becomes more active, or that diseased brain tissue becomes more active. .
"We also analyzed more than 800 proteins and finally found four proteins that may have an impact on the rate of aging."
Song He took out his cell phone, pulled out a few photos, and handed them to Xiang Xiaotong.
The photos are laboratory data taken, with densely packed small characters that must be magnified by hand to see clearly.
Xiang Xiaotong was holding the screen to look at the data, while Song He was talking next to him.
"These four proteins are based on mouse parabiosis experiments, we summarized some more practical proteins, and then improved them by imitating the protein structure, that is, new artificial proteins."
"Protein A is modified from a type of apolipoprotein A produced by the liver and plays a role in blood clotting. High levels of apolipoprotein A can trigger atherosclerosis, leading to heart disease and stroke."
"So we made protein A that does not have atherosclerosis and has similar functions, and it was a great success. It can inhibit the secretion of apolipoprotein A and at the same time shoulder the coagulation work of apolipoprotein A."
"What is the effect of extending life?" Xiang Xiaotong asked.
"The test has not been completed yet, but there is a guess value of seven months per unit!" Song He said, "Every time the protein A content in the blood increases by one unit, the liver indicators will become younger by about seven months! At least within reasonable limits. This is the pattern within the concentration.”
"Awesome!" Xiang Xiaotong exclaimed in a low voice.
"Then there is protein B, which is modified from the vascular cell adhesion molecule." Song He spoke quickly, "The vascular cell adhesion molecule also has a coagulation effect and can control blood vessel dilation, but when the content is too high, it can cause vascular inflammation. "
"So you have improved protein B, which is difficult to cause vascular inflammation and can be used to replace vascular cell adhesion molecules?" Xiang Xiaotong's mind was spinning quickly.
"right!"
"Effectiveness of the medicine?"
"Three to five years younger, mainly improving blood vessel elasticity."
"Awesome!" Xiang Xiaotong's eyes have changed, "Where are protein C and protein D?"
"Protein C and protein D should actually be combined into the same protein, but we have insufficient technology and can only make two types and mix them together." Song He said, "Both proteins are modified based on CD4-positive helper T cells. It draws on the achievements of academia, and some studies have pointed out that the content of CD4 cells in the bodies of long-lived people is different from that of ordinary people."
"Effectiveness?" Xiang Xiaotong said directly.
"I don't know." Song He shook his head.
"I don't know?" Xiang Xiaotong was startled, "You haven't even conducted experiments on mice and rats? How can you be sure it will work?"
Song He smiled particularly energetically, "Teacher, do you still remember the longest life span of the rats cultivated by Dr. Kacher?"
"47 months?" Xiang Xiaotong narrowed his eyes, "What's wrong?"
"We are sprinting for this record!" Song He said in astonishment, "I stayed in school during the holidays to accompany academic exchange groups from various universities. I met a professor from Zhejiang University and borrowed a group of elderly rats from him some time ago. All of them were close to death. Dead of old age.”
"We are now raising these rats that are dying of old age and using various ingredients to try to extend their lifespan."
"The oldest ones among them have been injected with protein C and protein D. They will be 47 months old next week!"
"As long as they survive until next week, the world record for the age of an average rat will be broken!"
Xiang Xiaotong's mouth opened slightly, surprised, "Today is the weekend, when is their birthday next week?"
"The earliest Tuesday." Song He said, "That's the day after tomorrow. Whether the world record can be broken this time will be revealed in the next 48 hours!"
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